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Liente tse peli kapa tse 'nè tsa plasma e nang le platelet e ngata ka lengoleng la osteoarthritis ha lia ka tsa fetola li-synovial biomarkers, empa hape li ntlafalitse liphello tsa kliniki.

Ho ea ka tlhahlobo ea litsebi tsa indasteri tse amehang, ba ile ba bapisa liente tse peli le tse 'nè tsa intra-articular tsa plasma e ruileng ea platelet (PRP) mabapi le liphetoho tsa synovial cytokines le liphello tsa kliniki.Bakuli ba 125 ba nang le knee osteoarthritis (OA) ba ile ba fumana liente tsa PRP libeke tse ling le tse ling tse 6.Pele ho ente e 'ngoe le e' ngoe ea PRP, litabatabelo tsa synovial fluid li ile tsa bokelloa bakeng sa thuto.Bakuli ba ile ba aroloa ka liente tse peli kapa tse 'nè tsa PRP tsa intra-articular (lihlopha A le B, ka ho latellana).Liphetoho ho li-biomarker tsa synovial li ne li bapisoa le maemo a motheo lihlopheng ka bobeli, 'me liphello tsa kliniki li ile tsa hlahlojoa ho fihlela selemo se le seng.Bakuli ba mashome a robong a metso e mene ba qetileng pokello ea synovial fluid ba kenyelelitsoe tlhahlobo ea ho qetela, 51 sehlopheng sa A le 43 sehlopheng sa B. Ho ne ho se na phapang pakeng tsa lilemo tse bolelang, thobalano, boima ba 'mele (BMI), le boemo ba radiographic OA.Palo e bolelang palo ea platelet le lisele tse tšoeu tsa mali ho PRP e ne e le 430,000 / µL le 200 / µL, ka ho latellana.Synovial inflammatory cytokines (IL-1β, IL-6, IA-17A, le TNF-α), anti-inflammatory cytokines (IL) -4, IL-10, IL-13, le IL-1RA) li ne li sa fetohe, 'me Lintlha tsa kgolo (TGF-B1, VEGF, PDGF-AA le PDGF-BB) li ne li le qalong le pakeng tsa libeke tsa 6 ho Sehlopha sa A le libeke tsa 18. sehlopheng sa B. Litholoana tsa meriana lihlopheng ka bobeli li ntlafetse haholo ho tloha libeke tsa 6, ho kenyelletsa le Visual Analog Scale (VAS), Mehato ea Liphello tse tlalehiloeng ke mokuli [PROM;Western Ontario le McMaster Universities Osteoarthritis (WOMAC) Index le Short Form-12 (SF-12)], mehato e thehiloeng ts'ebetsong [PBMs;nako ea ho tsoha (TUG), liteko tsa 5 tsa ho lula (5 × SST), le liteko tsa metsotso ea 3 ea ho tsamaea (3-minute WT)]. Qetellong, liente tsa 2 kapa 4 tsa intra-articular tsa PRP libeke tse ling le tse ling tsa 6 ka lengole. OA ha e bontše liphetoho ho synovial cytokines le lintlha tsa kholo, empa hape e ntlafalitse liphello tsa kliniki ho tloha libeke tse 6 ho isa ho selemo se le seng.


Nako ea poso: Mar-03-2022