Kopo ea meriana le lipatlisiso tsa PRP ka mafu a tloaelehileng a lengole
Platelet-rich plasma (PRP) ke plasma e entsoeng haholo-holo ka liplatelete le lisele tse tšoeu tsa mali tse fumanoang ka centrifugation ea mali a peripheral autologous.Palo e kholo ea lintlha tsa kholo le li-cytokine li bolokiloe ka har'a α granules ea liplatelete.Ha liplatelete li sebelisoa, li-granules tsa tsona tsa α li lokolla palo e kholo ea lintlha tsa kholo.Liphuputso li bontšitse hore lintlha tsena tsa ho hōla ha lisele li ka khothalletsa phapang ea lisele, ho ata, matrix a extracellular le collagen synthesis, kahoo ho khothalletsa ho tsosolosoa le ho lokisoa ha lefufuru la articular le ligament letse dinglisele.Ka nako e ts'oanang, e ka boela ea ntlafatsa karabelo ea ho ruruha ea sebaka sa lesion le ho fokotsa matšoao a kliniki a bakuli.Ntle le lintlha tsena tsa kholo ea lisele, PRP e boetse e na le palo e kholo ea lisele tse tšoeu tsa mali.Lisele tsena tse tšoeu tsa mali le liplatelete li ka lokolla mefuta e fapaneng ea li-peptide tse thibelang likokoana-hloko ho tlama likokoana-hloko, ho thibela le ho bolaea likokoana-hloko, le ho bapala karolo ea antibacterial.
PRP e 'nile ea sebelisoa haholo lefapheng la masapo a masapo ka lebaka la ts'ebetso ea eona e bonolo ea tlhahiso, tšebeliso e bonolo le litšenyehelo tse tlaase, haholo-holo ho phekola mafu a mangole lilemong tsa morao tjena.Sehlooho sena se tla tšohla ts'ebeliso ea bongaka le lipatlisiso tsa plasma e nang le platelet e ngata ka knee osteoarthritis (KOA), kotsi ea meniscus, kotsi ea cruciate ligament, knee synovitis le mafu a mang a tloaelehileng a lengole.
Theknoloji ea kopo ea PRP
PRP e sa sebetseng le ho lokolloa ha PRP e entsoeng ke metsi 'me e ka kenngoa,' me PRP e sa sebetseng e ka laoloa ka ho eketsa calcium chloride kapa thrombin ka maiketsetso ho laola nako ea agglutination e le hore gel e ka thehoa ka mor'a hore e fihle sebakeng se lebisitsoeng, ho fihlela sepheo sa tokollo e tsitsitseng ea lintlha tsa kholo.
Phekolo ea PRP ea KOA
KOA ke lefu la lengole le senyehang le khetholloang ke ho timetsoa ho tsoelang pele ha lefufuru la articular.Bongata ba bakuli ke ba lilemong tse mahareng le batho ba baholo.Lipontšo tsa kliniki tsa KOA ke bohloko ba mangole, ho ruruha le ho fokotsa mosebetsi.Ho se leka-lekane pakeng tsa motsoako le ho senyeha ha matrix a articular cartilage ke motheo oa ketsahalo ea KOA.Ka hona, ho khothalletsa ho lokisoa ha lefufuru le ho laola ho leka-lekana ha matrix a lefufuru ke senotlolo sa phekolo ea lona.
Hajoale, bakuli ba bangata ba KOA ba loketse kalafo e bolokang nako.Ente e kopanetsoeng ea lengole ea hyaluronic acid, glucocorticoids le lithethefatsi tse ling le litlhare tsa molomo tse seng tsa steroid tse thibelang ho ruruha hangata li sebelisoa kalafo e bolokang matla.Ka ho teba ha lipatlisiso ka PRP ke litsebi tsa malapeng le tsa linaheng tse ling, phekolo ea KOA e nang le PRP e se e atile le ho feta lilemong tsa morao tjena.
Mokhoa oa ts'ebetso:
1. Khothalletsa ho ata ha li-chondrocyte:
Ka ho lekanya phello ea PRP ho sebetsa ha li-chondrocyte tsa mmutla, Wu J et al.e fumane hore PRP e ntlafalitse ho ata ha li-chondrocyte, 'me ho nahanoa hore PRP e ka sireletsa li-chondrocyte tsa IL-1β-activated ka ho thibela phetoho ea pontšo ea Wnt / β-catenin.
2. Thibelo ea chondrocyte inflammatory reaction and degeneration:
Ha e sebelisoa, PRP e lokolla palo e kholo ea lintho tse khahlanong le ho ruruha, tse kang IL-1RA, TNF-Rⅰ, ⅱ, joalo-joalo Il-1ra e ka thibela ts'ebetso ea IL-1 ka ho thibela IL-1 receptor, le TNF-Rⅰ le ⅱ e ka thibela tsela ea matšoao e amanang le TNF-α.
Boithuto bo sebetsang:
Lipontšo tse ka sehloohong ke ho imolla bohloko le ntlafatso ea mosebetsi oa lengole.
Lin KY le ba bang.bapisa ente ea intra-articular ea LP-PRP e nang le hyaluronic acid le saline e tloaelehileng, 'me a fumana hore phello ea phekolo ea lihlopha tse peli tsa pele e ne e le molemo ho feta ea sehlopha se tloaelehileng sa saline ka nako e khutšoanyane, e leng se netefalitseng phello ea kliniki ea LP-PRP. le hyaluronic acid, le ho shebella nako e telele (ka mor'a selemo sa 1) ho bontšitse hore phello ea LP-PRP e ne e le molemo.Liphuputso tse ling li kopantsoe le PRP le hyaluronic acid, 'me li fumane hore motsoako oa PRP le hyaluronic acid ha o khone ho kokobetsa bohloko feela le ho ntlafatsa mosebetsi, empa hape o tiisa ho tsosolosoa ha lefufuru la articular ka X-ray.
Leha ho le joalo, Filardo G et al.o ne a lumela hore sehlopha sa PRP le sehlopha sa sodium hyaluronate se atlehile ho ntlafatsa ts'ebetso ea lengole le matšoao ka thuto e laoloang ka nako e telele, empa ha ho phapang e khōlō e ileng ea fumanoa.Ho ile ha fumanoa hore tsela ea tsamaiso ea PRP e na le phello e itseng ho phello ea phekolo ea KOA.Du W et al.e ile ea tšoara KOA ka ente ea intravarticular ea PRP le ente ea extraarticular, 'me ea hlokomela lintlha tsa VAS le Lysholm pele ho meriana le 1 le likhoeli tsa 6 ka mor'a meriana.Ba fumane hore mekhoa ea ente ka bobeli e ka ntlafatsa lintlha tsa VAS le Lysholm ka nako e khutšoanyane, empa phello ea sehlopha sa ente ea intra-articular e ne e le molemo ho feta sehlopha sa ente ea extraarticular ka mor'a likhoeli tsa 6.Taniguchi Y et al.e arolelitse thuto ka phekolo ea KOA e itekanetseng ho isa ho e matla ka ente ea intraluminal e kopantsoeng le ente ea intraluminal ea sehlopha sa PRP, ente ea intraluminal ea sehlopha sa PRP le ente ea intraluminal ea HA sehlopha.Phuputso e bontšitse hore motsoako oa ente ea intraluminal ea PRP le ente ea intraluminal ea PRP e ne e le molemo ho feta ente ea intraluminal ea PRP kapa HA bonyane likhoeli tsa 18 ho ntlafatsa lintlha tsa VAS le WOMAC.
(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)
Nako ea poso: Nov-04-2022