Liplatelete, e le likaroloana tsa lisele tse tsoang ho megakaryocyte ea masapo, li khetholloa ke ho ba sieo ha nuclei.Platelet e 'ngoe le e' ngoe e na le mefuta e meraro ea likaroloana, e leng α Granules, 'mele e teteaneng le li-lysosome tse nang le bongata bo fapaneng.Ho kenyelletsa α The granules e ruile liprotheine tse fapaneng tse fetang 300, joalo ka vascular endothelial activating factor, leukocyte chemotactic factor, activating factor, tokiso ea lisele tse amanang le kholo le antibacterial peptide, e amehang lits'ebetsong tse ngata tsa 'mele le tsa pathological, joalo ka pholiso ea maqeba. , angiogenesis le ho itšireletsa mafung.
'Mele o teteaneng o na le metsoako e phahameng ea adenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2+, Mg2+ le 5-hydroxytryptamine.Li-lysosomes li na le mefuta e fapaneng ea li-protease tsa tsoekere, tse kang glycosidase, proteases, liprotheine tsa cationic le liprotheine tse nang le ts'ebetso ea bactericidal.Li-GF tsena li lokolloa maling ka mor'a ho sebetsa ha platelet.
GF e tsosa karabelo ea "cascade" ka ho tlama mefuta e fapaneng ea li-membrane tsa lisele, 'me e kenya tšebetsong tšebetso e itseng ts'ebetsong ea ho nchafatsa lisele.Hona joale, GF e ithutoang ka ho fetisisa ke platelet derived growth factor (PDGF) le ho fetola sekhahla sa kholo (TGF- β (TGF- β) , Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), connective tissue growth factor (CTGF) le insulin-like growth factor-1 (IGF-1). Li-GF tsena li thusa ho lokisa mesifa, tendon, ligament le lisele tse ling ka ho khothalletsa ho ata ha lisele le ho arohana, angiogenesis le mekhoa e meng, ebe li bapala tse tšoanang. karolo.
Tšebeliso ea PRP ho Vitiligo
Vitiligo, joalo ka lefu le tloaelehileng la autoimmune, hammoho le lefu la letlalo le senyehileng, le na le phello e mpe ho kelello ea bakuli mme e ama haholo bophelo ba bakuli.Ho akaretsa, ketsahalo ea vitiligo ke phello ea ho sebelisana ha liphatsa tsa lefutso le maemo a tikoloho, e leng se etsang hore letlalo la melanocyte le hlaseloe le ho senyeha ke tsamaiso ea autoimmune.Hona joale, le hoja ho na le liphekolo tse ngata tsa vitiligo, hangata ha li sebetse hantle, 'me liphekolo tse ngata ha li na bopaki ba meriana e thehiloeng bopaking.Lilemong tsa morao tjena, ka tlhahlobo e tsoelang pele ea pathogenesis ea vitiligo, mekhoa e meng e mecha ea phekolo e 'nile ea sebelisoa kamehla.E le mokhoa o sebetsang oa ho phekola vitiligo, PRP e 'nile ea sebelisoa khafetsa.
Hajoale, 308 nm excimer laser le 311 nm narrow band ultraviolet (NB-UVB) le litheknoloji tse ling tsa phototherapy li ntse li hlokomeloa ka katleho ea tsona ho bakuli ba nang le vitiligo.Hona joale, tšebeliso ea autologous PRP subcutaneous microneedle injection e kopantsoeng le phototherapy ho bakuli ba nang le vitiligo e tsitsitseng e entse tsoelo-pele e kholo.Abdelghani et al.ba fumane liphuputsong tsa bona hore ente ea autologous PRP subcutaneous microneedle e kopantsoeng le phototherapy ea NB-UVB e ka khutsufatsa haholo nako eohle ea phekolo ea bakuli ba vitiligo.
Khattab et al.e ile ea tšoara bakuli ba nang le vitiligo e tsitsitseng e sa segmental ka laser ea 308 nm excimer le PRP, 'me e fumane liphello tse ntle.Ho ile ha fumanoa hore motsoako oa tsena tse peli o ka ntlafatsa ka katleho sekhahla sa leucoplakia recolor, ho khutsufatsa nako ea phekolo, le ho qoba karabelo e mpe ea tšebeliso ea nako e telele ea 308 nm excimer laser irradiation.Liphuputso tsena li fana ka maikutlo a hore PRP e kopantsoe le phototherapy ke mokhoa o atlehang oa ho phekola vitiligo.
Leha ho le joalo, Ibrahim le liphuputso tse ling li boetse li fana ka maikutlo a hore PRP feela ha e sebetse ho phekola vitiligo.Kadry et al.e ile ea etsa thuto e laoloang ka mokhoa o sa reroang mabapi le phekolo ea vitiligo le PRP e kopantsoeng le carbon dioxide dot matrix laser, 'me ea fumana hore PRP e kopantsoeng le carbon dioxide dot matrix laser le PRP feela e fihletse phello e ntle ea ho hlahisa mebala.Har'a bona, PRP e kopantsoeng le carbon dioxide dot matrix laser e ne e e-na le phello e ntle ka ho fetisisa ea ho hlahisa mebala, 'me PRP feela e ne e finyelletse ho hlahisa mebala e itekanetseng leukoplakia.Phello ea ho hlahisa mebala ea PRP feela e ne e le betere ho feta ea carbon dioxide dot matrix laser feela kalafong ea vitiligo.
Ts'ebetso e Kopantsoeng le PRP ho Phekolo ea Vitiligo
Vitiligo ke mofuta oa lefu la letlalo le khetholloang ke ho senyeha ha 'mala.Mekhoa e tloaelehileng ea phekolo e kenyelletsa phekolo ea lithethefatsi, phototherapy kapa opereishene, kapa motsoako oa mekhoa e mengata ea phekolo.Bakeng sa bakuli ba nang le vitiligo e tsitsitseng le phello e mpe ea phekolo e tloaelehileng, phekolo ea ho buuoa e ka ba mokhoa oa pele oa ho kenella.
Garg le ba bang.o sebelisitse PRP e le moemeli oa ho emisa lisele tsa epidermal, 'me a sebelisa Er: YAG laser ho sila matheba a masoeu, a fihletseng phello e ntle ea phekolo ho phekola bakuli ba tsitsitseng ba vitiligo.Phuputsong ena, bakuli ba 10 ba nang le vitiligo e tsitsitseng ba ile ba ngolisoa 'me ho ile ha fumanoa maqeba a 20.Likarolong tsa 20, likokoana-hloko tsa 12 (60%) li bontšitse ho hlaphoheloa ka ho feletseng ha pigment, lisosa tsa 2 (10%) li bontšitse ho hlaphoheloa ha mebala e kholo, lisosa tsa 4 (20%) li bontšitse ho hlaphoheloa ha pigment ka mokhoa o itekanetseng, 'me liso tsa 2 (10%) ha lia ka tsa bontša ntlafatso e kholo.Ho hlaphoheloa ha maoto, manonyeletso a mangole, sefahleho le molala ho totobetse ka ho fetisisa, ha ho hlaphoheloa ha lipheletsong ho fokola.
Nimitha et al.e sebelisitse ho emisoa ha PRP ea lisele tsa epidermal ho lokisa ho emisoa le ho emisoa ha phosphate buffer ea lisele tsa epidermal ho bapisa le ho bona ho hlaphoheloa ha bona ha pigment ho bakuli ba nang le vitiligo e tsitsitseng.Bakuli ba 21 ba tsitsitseng ba vitiligo ba kenyelelitsoe mme matheba a masoeu a 42 a ile a fumanoa.Ka karolelano nako e tsitsitseng ea vitiligo e ne e le lilemo tse 4,5.Bakuli ba bangata ba bontšitse ho hlaphoheloa ha 'mala o monyane ho isa ho oval discrete pigment hoo e ka bang likhoeli tse 1-3 kamora kalafo.Nakong ea likhoeli tsa 6 tsa ho latela, palo e bolelang ea ho hlaphoheloa ha pigment e ne e le 75.6% sehlopheng sa PRP le 65% ho sehlopha se seng sa PRP.Phapang ea sebaka sa ho hlaphoheloa ha pigment pakeng tsa sehlopha sa PRP le sehlopha se seng sa PRP se ne se le bohlokoa haholo.Sehlopha sa PRP se bonts'itse ho hlaphoheloa hantle ha pigment.Ha ho hlahlojoa sekhahla sa ho hlaphoheloa ha pigment ho bakuli ba nang le segmental vitiligo, ho ne ho se na phapang e khōlō pakeng tsa sehlopha sa PRP le sehlopha se seng sa PRP.
Tšebeliso ea PRP ho Chloasma
Melasma ke mofuta oa lefu la letlalo le nang le 'mala oa sefahleho, le hlahang haholo sefahlehong sa basali ba pepesehelang khanya ea ultraviolet khafetsa mme ba na le' mala o tebileng oa letlalo.Pathogenesis ea eona ha e so hlakisoe ka botlalo, 'me ho thata ho e phekola ebile ho bonolo ho ipheta.Hajoale, kalafo ea chloasma hangata e sebelisa mokhoa o kopaneng oa kalafo.Le hoja ente ea subcutaneous ea PRP e na le mekhoa e fapaneng ea phekolo ea chloasma, katleho ea bakuli ha e khotsofatse haholo, 'me ho bonolo ho khutlela mokhoeng ka mor'a ho emisa phekolo.'Me lithethefatsi tse nooang tse kang tranexamic acid le glutathione li ka baka ho ferekana ka mpeng, lefu la ho ilela khoeli, hlooho, esita le ho thehoa ha methapo e tebileng ea thrombosis.
Ho hlahloba phekolo e ncha ea chloasma ke tataiso ea bohlokoa lipatlisisong tsa chloasma.Ho tlalehoa hore PRP e ka ntlafatsa haholo maqeba a letlalo a bakuli ba nang le melasma.Cay ı rl ı Et al.e tlaleha hore mosali ea lilemo li 27 o ile a fumana ente ea subcutaneous microneedle ea PRP matsatsi a mang le a mang a 15.Qetellong ea phekolo ea boraro ea PRP, ho ile ha hlokomeloa hore sebaka sa ho hlaphoheloa ha epidermal pigment e ne e le> 80%, 'me ha hoa ka ha e-ba le ho pheta-pheta nakong ea likhoeli tse 6.Sirithanabadeekul et al.e sebelisitse PRP bakeng sa phekolo ea chloasma ho etsa RCT e matla haholoanyane, e leng se ileng sa tiisa ka ho eketsehileng katleho ea ente ea PRP ea intracutaneous bakeng sa phekolo ea chloasma.
Hofny le ba bang.e sebelisitse mokhoa oa immunohistochemical ho tsamaisa TGF ka ente ea subcutaneous microneedle ea PRP ka har'a liso tsa letlalo la bakuli ba nang le chloasma le likarolo tse tloaelehileng- β Papiso ea polelo ea protheine e bontšitse hore pele ho phekolo ea PRP, liso tsa letlalo la bakuli ba nang le chloasma le TGF ho pota-potile letlalo la letlalo, β Polelo ea protheine e ne e le tlase haholo ho feta ea letlalo le phetseng hantle (P <0.05).Ka mor'a phekolo ea PRP, TGF ea letlalo la letlalo ho bakuli ba nang le chloasma- β Polelo ea protheine e ile ea eketseha haholo.Ketsahalo ena e bontša hore phello ea ntlafatso ea PRP ho bakuli ba chloasma e ka finyelloa ka ho eketsa TGF ea letlalo la letlalo- β Polelo ea protheine e finyella phello ea phekolo ho chloasma.
Photoelectric Technology e Kopantsoeng le Subcutaneous Ente ea PRP bakeng sa Kalafo ea Chloasma
Ka tsoelo-pele e tsoelang pele ea theknoloji ea photoelectric, karolo ea eona ea phekolo ea chloasma e hohetse tlhokomelo e eketsehileng ea bafuputsi.Hajoale, li-lasers tse sebelisoang ho phekola chloasma li kenyelletsa laser ea Q-switched, laser lattice, lebone le matla la pulsed, laser ea cuprous bromide le mehato e meng ea kalafo.Molao-motheo ke hore ho phatloha ha leseli ho etsoa bakeng sa likaroloana tsa melanin ka hare kapa pakeng tsa melanocyte ka khetho ea matla, 'me mosebetsi oa melanocyte ha o sebetse kapa o thibeloa ka matla a fokolang le ho phatloha ka makhetlo a mangata,' me ka nako e ts'oanang, ho phatloha ho hoholo ha likaroloana tsa melanin. e etsoa, E ka etsa hore likaroloana tsa melanin li be nyane 'me li be bonolo haholoanyane ho metsoa le ho ntšoa ke' mele.
Su Bifeng et al.phekolo ea chloasma ka ente ea khanya ea metsi ea PRP e kopantsoeng le Q switched Nd: YAG 1064nm laser.Har'a bakuli ba 100 ba nang le chloasma, bakuli ba 15 sehlopheng sa PRP + laser ba ile ba phekoloa ha e le hantle, bakuli ba 22 ba ile ba ntlafatsoa haholo, bakuli ba 11 ba ile ba ntlafatsoa, 'me mokuli a le mong o ne a sa sebetse;Sehlopheng sa laser feela, linyeoe tse 8 li ile tsa phekoloa, linyeoe tse 21 li ne li sebetsa hantle, linyeoe tse 18 li ile tsa ntlafatsoa, 'me tse 3 li ne li sa sebetse.Phapang pakeng tsa lihlopha tsena tse peli e ne e le ea bohlokoa ka lipalo (P <0.05).Peng Guokai le Song Jiquan ba netefalitse hape katleho ea laser ea Q-switched e kopantsoeng le PRP kalafong ea chloasma ea sefahleho.Liphello li bontšitse hore laser ea Q-switched e kopantsoeng le PRP e ne e atleha ho phekola chloasma ea sefahleho
Ho ea ka lipatlisiso tsa morao-rao mabapi le PRP ka dermatoses e mebala-bala, mokhoa o ka khonehang oa PRP ho phekola chloasma ke hore PRP e eketsa TGF ea letlalo la letlalo- β Polelo ea protheine e ka ntlafatsa bakuli ba melasma.Ntlafatso ea PRP ho liso tsa letlalo la bakuli ba vitiligo e kanna ea amana le limolek'hule tsa α Adhesion tse patiloeng ke granules li amana le ntlafatso ea tikoloho ea lehae ea liso tsa vitiligo ka li-cytokine.Ho qala ha vitiligo ho amana haufi-ufi le tšireletso e sa tloaelehang ea maqeba a letlalo.Liphuputso li fumane hore ho se tloaelehe ha 'mele oa ho itšireletsa mafung ho bakuli ba vitiligo ho amana le ho hlōleha ha keratinocyte le melanocyte letlalong ho hanyetsa tšenyo ea melanocyte e bakoang ke mefuta e sa tšoaneng ea ho ruruha le li-chemokine tse lokolloa ts'ebetsong ea intracellular oxidative stress.Leha ho le joalo, lintlha tse fapaneng tsa kholo ea liplatelete tse patiloeng ke PRP le mefuta e fapaneng ea li-cytokine tse khahlanong le ho ruruha tse lokollotsoeng ke liplatelete, joalo ka soluble tumor necrosis factor receptor I, IL-4 le IL-10, e leng bahanyetsi ba interleukin-1 receptor, phetha karolo e itseng ho laola ho leka-lekana ha 'mele ea ho itšireletsa mafung ea maqeba a letlalo.
(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)
Nako ea poso: Nov-24-2022