Platelet Rich Plasma (PRP)
PRP e hohetse tlhokomelo hobane e na le mefuta e sa tšoaneng ea ho hōla, 'me e sebelisoa haholo ho buuoa ka maxillofacial, orthopedics, opereishene ea polasetiki, ophthalmology le masimo a mang.Ka 2006, Uebel et al.pele o ile a leka ho thibela lihlopha tsa follicular hore li fetisetsoe ka PRP 'me li hlokometse hore ha li bapisoa le sebaka sa ho laola letlalo la hlooho, sebaka sa ho fetisetsa moriri se entsoeng ka PRP se ile sa pholoha 18.7 follicular units / cm2, ha sehlopha sa taolo se ntse se pholoha lihlopha tsa 16.4 follicular./cm2, letsoalo le eketsehile ka 15.1%.Ka hona, ho nahanoa hore lintlha tsa ho hōla tse lokolloang ke liplatelete li ka 'na tsa sebetsa liseleng tsa stem tsa moriri oa moriri, tsa susumetsa phapang ea lisele tsa stem le ho khothalletsa ho thehoa ha methapo e mecha ea mali.
Ka 2011, Takikawa et al.e sebelisitse saline e tloaelehileng, PRP, heparin-protamine microparticles e kopantsoeng le PRP (PRP & D / P MPs) ho kenya ente e ka tlaase ho bakuli ba AGA ho theha taolo.Liphetho li bonts'itse hore karolo ea moriri oa sehlopha sa PRP le sehlopha sa MPs ea PRP&D/P e eketsehile haholo, likhoele tsa collagen le li-fibroblasts tse melang ea moriri li ile tsa ata ka tlas'a microscope, le methapo ea mali e potileng. lithapo tsa moriri li ile tsa ata.
PRP e na le lintlha tse ngata tsa khōlo e entsoeng ka platelet.Liprotheine tsena tsa bohlokoa li laola ho falla ha lisele, ho khomarela, ho ata, le ho arohana, ho khothalletsa ho bokella matrix a extracellular, 'me lintho tse ngata tsa kgolo li khothalletsa ho hōla ha moriri ka mafolofolo: lintlha tsa ho hōla ho PRP li sebelisana le li-follicles tsa moriri.Motsoako oa lisele tse nang le li-bulge stem li etsa hore ho ata ha li-follicle tsa moriri, li hlahise lihlopha tsa follicular, 'me li khothalletsa ho tsosolosoa ha moriri.Ho feta moo, e ka kenya tšebetsong karabelo e tlase ea cascade le ho khothaletsa angiogenesis.
Boemo ba Hona joale ba PRP ho Phekolo ea AGA
Ho ntse ho se na tumellano mabapi le mokhoa oa ho itokisa le ntlha ea ntlafatso ea platelet ea PRP;mekhoa ea phekolo e fapana ka palo ea phekolo, nako ea nako, nako ea ho khutlela morao, mokhoa oa ho entoa, le hore na ho sebelisoa lithethefatsi tse kopantsoeng.
Mapar et al.e kenyelelitse bakuli ba banna ba 17 ba nang le sethaleng sa IV ho ea ho VI (mokhoa oa ho etsa lipalo oa Hamilton-Norwood), 'me liphello ha li bontše phapang pakeng tsa liente tsa PRP le placebo, empa thuto e ile ea etsa liente tsa 2 feela,' me palo ea phekolo e ne e le nyenyane haholo.Liphetho li bulehetse lipotso.;
Gkini et al o fumane hore bakuli ba nang le sethala se tlase ba bontšitse karabelo e phahameng ho kalafo ea PRP;pono ena e tiisitsoe ke Qu et al, e neng e kenyelletsa bakuli ba 51 ba banna le ba 42 ba nang le sethaleng sa II-V ho banna le 'na ho basali ~ Stage III (mokhahlelo ke mokhoa oa Hamilton-Norwood le Ludwig), liphello li bontša hore phekolo ea PRP e na le phapang ea lipalo ho bakuli ba nang le mekhahlelo e fapaneng ea banna le basali, empa katleho ea boemo bo tlaase le boemo bo phahameng bo molemo, kahoo bafuputsi ba khothalletsa II, bakuli ba banna ba Stage III le bakuli ba basali ba sethaleng sa I ba ile ba phekoloa ka PRP.
Ntho e Atlehang ea ho Ruisa
Phapang ea mekhoa ea ho itokisa ea PRP thutong e 'ngoe le e' ngoe e lebisitse ho mefuta e fapaneng ea maruo ea PRP thutong ka 'ngoe, eo boholo ba eona e neng e tsepamisitsoe lipakeng tsa 2 le 6 linako.Platelet degranulation e lokolla palo e kholo ea lintlha tsa ho hōla, e laola ho falla ha lisele, ho khomarela, ho ata le ho arohana, ho susumetsa moriri oa moriri oa ho ata ha lisele tsa moriri, li-tissue vascularization, le ho khothalletsa ho bokella matrix a extracellular.Ka nako e ts'oanang, mochine oa microneedling le laser therapy ea matla a tlaase e nkoa e le E Hlahisa tšenyo ea lisele tse laoloang 'me e susumetsa ts'ebetso ea tlhaho ea platelet degranulation, e khethollang boleng ba sehlahisoa sa PRP ho itšetlehile ka mosebetsi oa eona oa likokoana-hloko.Ka hona, ho bohlokoa ho hlahloba khatello e sebetsang ea PRP.Liphuputso tse ling li lumela hore PRP e nang le lesaka la ho ntlafatsa makhetlo a 1-3 e sebetsa ho feta lesaka le phahameng la ho rua, empa Ayatollahi et al.e sebelisitse PRP e nang le mahloriso a maruo a linako tsa 1.6 bakeng sa phekolo, 'me liphello li bontšitse hore phekolo ea bakuli ba AGA e ne e sa sebetse,' me e lumela hore PRP Tlhokomelo e sebetsang e lokela ho ba makhetlo a 4 ~ 7.
Palo ea Liphekolo, Nako ea Nako le Nako ea Boikhutso
Lithuto tsa Mapar et al.le Puig et al.ka bobeli ba ile ba fumana liphello tse mpe.Palo ea liphekolo tsa PRP ho liprothokholo tsena tse peli tsa thuto e ne e le 1 le linako tsa 2, ka ho latellana, tse neng li le tlase ho feta lithuto tse ling (haholo-holo linako tsa 3-6).Picard et al.ba fumane hore katleho ea PRP e fihlile tlhōrōng ea eona ka mor'a phekolo ea 3 ho ea ho 5, kahoo ba lumela hore ho ka 'na ha hlokahala liphekolo tse fetang 3 ho ntlafatsa matšoao a ho lahleheloa ke moriri.
Tlhahlobo ea Gupta le Carviel e fumane hore boholo ba lithuto tse teng li ne li e-na le nako ea phekolo ea khoeli ea 1, 'me ka lebaka la palo e fokolang ea lithuto, liphello tsa phekolo ka liente tsa khoeli le khoeli tsa PRP ha lia ka tsa bapisoa le maqhubu a mang a ente, joalo ka liente tsa beke le beke tsa PRP.
Phuputso ea Hausauer le Jones [20] e bontšitse hore batho ba ileng ba fumana liente tsa khoeli le khoeli ba ne ba e-na le ntlafatso e kholo ea palo ea moriri ha ba bapisoa le makhetlo a mangata a liente likhoeli tse ling le tse ling tsa 3 (P <0.001);Schiavone et al.[21] o ile a etsa qeto ea hore, Kalafo e lokela ho phetoa likhoeli tse 10 ho isa ho tse 12 ka mor'a ho fela ha phekolo;Balichaba et al.e lateloa ka lilemo tse 2, nako e telele ka ho fetisisa ea ho latela lithuto tsohle, 'me e fumane hore bakuli ba bang ba khutlile likhoeling tsa 12 (maemo a 4/20), le ho bakuli ba 16 Matšoao a bonahala haholo ka likhoeli.
Ts'ebetsong ea Sclafani, ho ile ha fumanoa hore katleho ea bakuli e fokotsehile haholo likhoeli tsa 4 ka mor'a hore phekolo e fele.Picard et al.a bua ka liphello 'me a fana ka keletso e lumellanang ea phekolo: ka mor'a nako e tloaelehileng ea phekolo ea 3 ea khoeli e le' ngoe, phekolo e lokela ho etsoa ka makhetlo a mang le a mang a mararo.Kalafo e matla ea khoeli le khoeli.Leha ho le joalo, Sclafani ha aa ka a hlalosa karo-karolelano ea matla a platelet ea litokisetso tse sebelisoang ts'ebetsong ea phekolo.Thutong ena, 8-9 ml ea litokisetso tsa matrix tse nang le platelet-rich fibrin li ile tsa lokisoa ho tloha ho 18 ml ea mali a peripheral (PRP e ntšitsoeng e ile ea eketsoa ho CaCl2 vacuum tube, 'me sekhomaretsi sa fibrin se ile sa kenngoa sekhomaretsing sa fibrin. ente pele e thehoa) , re lumela hore lemeno le matlafatsang la liplatelete tokisetsong ena le ka ’na la se ke la lekana, ’me ho hlokahala bopaki bo eketsehileng ho e tšehetsa.
Mokhoa oa ho Enta
Bongata ba mekhoa ea ente ke ente ea intradermal le subcutaneous injection.Bafuputsi ba buisane ka phello ea mokhoa oa tsamaiso ho phello ea phekolo.Gupta le Carviel ba khothalelitse ente ea subcutaneous.Bafuputsi ba bang ba sebelisa ente ea intradermal.Ente ea Intradermal e ka liehisa ho kena ha PRP maling, ea fokotsa sekhahla sa metabolic, ea lelefatsa nako ea ketso ea lehae, le ho eketsa ts'usumetso ea dermis ho khothaletsa kholo ea moriri.le botebo ha bo tshwane.Re khothaletsa hore mokhoa oa ente ea Nappage o sebelisoe ka thata ha o etsa liente tsa intradermal ho qhelela ka thoko tšusumetso ea liphapang tsa ente, 'me re khothaletsa bakuli hore ba beole moriri o mokhuts'oane ho hlokomela tataiso ea moriri, le ho lokisa angle ea ho kenya nale ka nepo ho ea ka eona. tataiso ea ho hōla e le hore ntlha ea nale e ka fihla ho pota-potile follicle ea moriri , ka hona ho eketsa mahloriso a PRP sebakeng sa moriri oa moriri.Litlhahiso tsena tse mabapi le mekhoa ea ente ke tsa litšupiso feela, kaha ha ho liphuputso tse bapisang ka ho toba melemo le bofokoli ba mekhoa e fapaneng ea ente.
Phekolo e Kopanetsoeng
Jha et al.e sebelisitse PRP e kopantsoeng le microneedling le 5% minoxidil e kopantsoeng phekolo ho bontša katleho e ntle bopaking ba sepheo le boitlhahlobo ba mokuli.Re ntse re tobane le liphephetso tsa ho leka-lekanya mekhoa ea phekolo bakeng sa PRP.Le hoja liphuputso tse ngata li sebelisa mekhoa ea boleng le ea bongata ho hlahloba ntlafatso ea matšoao ka mor'a phekolo, joalo ka palo ea moriri oa ho qetela, palo ea moriri oa vellus, palo ea moriri, boima, botenya, joalo-joalo, mekhoa ea ho hlahloba e fapana haholo;ho phaella moo, ho lokisetsa PRP Ha ho na mokhoa o ts'oanang oa mokhoa, ho eketsa activator, nako ea centrifugation le lebelo, mahloriso a platelet, joalo-joalo;mekhoa ea phekolo e fapana ka palo ea phekolo, nako ea nako, nako ea ho khutlela morao, mokhoa oa ente, le hore na ho kopanngoa meriana;khetho ea lisampole thutong ha se Stratification ka lilemo, bong, le tekanyo ea alopecia e ile ea fifatsa tlhahlobo ea litlamorao tsa kalafo ea PRP.Nakong e tlang, ho sa ntse ho hlokahala lithuto tse ngata tse nang le mekhoa e metle ea ho itlhokomela ho hlakisa mekhoa e fapaneng ea phekolo, 'me tlhahlobo e eketsehileng ea stratified ea lintlha tse kang lilemo tsa mokuli, tekano le tekanyo ea ho lahleheloa ke moriri e ka ntlafatsoa butle-butle.
(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)
Nako ea poso: Aug-02-2022