PRP e sebetsa ka degranulation ea alpha granules ho tloha liplatelete, tse nang le lintlha tse 'maloa tsa kholo.Ts'ebetso e sebetsang ea lintlha tsena tsa kholo e qalisoa ke ts'ebetso ea ho kopanya mali 'me e qala ka hare ho metsotso e 10 ea coagulation.Ho feta 95% ea lintlha tsa kholo tse entsoeng esale pele li patoa nakong ea hora e le 'ngoe.Ka hona, PRP e tlameha ho lokisoa sebakeng sa anticoagulant 'me e lokela ho sebelisoa ka li-grafts, flaps, kapa maqeba ka hare ho metsotso ea 10 ea ho qala ha clot.Lithuto tse sa sebeliseng mali a anticoagulated ha se lithuto tsa 'nete tsa PRP ebile lia khelosa.
Ha liplatelete li ntse li sebelisoa ke mokhoa oa ho koala, lintlha tsa kholo li patoa ho tloha seleng ka lera la sele.Ts'ebetsong ena, likaroloana tsa alpha li kopana le lisele tsa platelet, 'me lintlha tsa kholo ea protheine li phethela boemo ba bioactive ka ho eketsa liketane tsa mahlakoreng a histone le carbohydrate ho liprotheine tsena.Ka hona, liplatelete tse senyehileng kapa tse sa sebetseng ke phekolo ea PRP ha li hlahise lintlha tsa kholo ea bioactive 'me li ka lebisa liphellong tse soabisang.Lintlha tsa khōlo e patiloeng li tlama hang-hang bokaholimo ba lisele tse ka har'a graft, flap, kapa leqeba ka li-receptor tsa transmembrane.
Liphuputso li bontšitse hore lisele tsa batho ba baholo tsa mesenchymal stem, osteoblasts, fibroblasts, lisele tsa endothelial, le lisele tsa epidermal li hlahisa li-receptor tsa lisele tsa lisele bakeng sa lintlha tsa kholo ho PRP.Li-receptor tsena tsa transmembrane le tsona li etsa hore ho be le ts'ebetso ea liprotheine tsa matšoao tsa ka hare tse lebisang polelong (ho notlolla) ea tatellano e tloaelehileng ea liphatsa tsa lefutso tsa cellular, joalo ka ho ata ha lisele, sebopeho sa matrix, sebopeho sa osteoid, collagen synthesis, jj.
Bohlokoa ba tsebo ena ke hore lintlha tsa kholo tsa PRP ha li kene ka seleng kapa khubung ea eona, ha li fetohe, li mpa li potlakisa ts'usumetso ea pholiso e tloaelehileng.Ka hona, PRP ha e na bokhoni ba ho susumetsa sebopeho sa hlahala.
Ka mor'a ho phatloha ha pele ha lintlha tsa kholo tse amanang le PRP, liplatelete lia kopanya le ho hlahisa lintlha tse eketsehileng tsa kholo bakeng sa matsatsi a 7 a setseng a nako ea bophelo ba tsona.Hang ha liplatelete li se li felile 'me li shoele, li-macrophage tse fihlang sebakeng seo ka methapo ea mali e susumelitsoeng ke platelet li hola ka hare ho nka karolo ea taolo ea pholiso ea maqeba ka ho pata lintlha tse ling tsa kholo hammoho le tse ling.Kahoo, palo ea liplatelete tse ho graft, leqeba kapa leqeba la mali tse khomaretsoeng lepheong ke tsona tse bontšang hore na leqeba leo le fola kapele hakae.PRP e eketsa palo eo feela.
Ke liplatelete tse kae tse lekaneng?
Liphuputso li bontšitse hore ho ata le ho arohana ha batho ba baholo ba MSCS ho amana ka ho toba le platelet concentration.Ba bonts'itse li-curve tsa karabelo ea lethal dose, tse bonts'ang hore karabelo e lekaneng ea lisele ho mahloriso a liplatelete e qalile ha makhetlo a mane ho isa ho a mahlano palo ea mantlha ea liplatelete e fihleloa.Phuputso e tšoanang e bontšitse hore ho eketseha ha platelet concentration ho boetse ho ntlafatsa ho ata ha fibroblast le tlhahiso ea mofuta oa I collagen, le hore boholo ba karabelo e ne e itšetlehile ka PH, ka karabelo e ntle ka ho fetisisa e hlahang maemong a pH a acidic haholoanyane.
Liphuputso tsena ha li bontše feela tlhokahalo ea lisebelisoa tsa ho tsepamisa mohopolo liplatelete tse lekaneng, empa hape li hlalosa liphello tse ntlafetseng tsa ho tsosolosoa ha masapo le liphello tse matlafatsang tsa lisele tse bonolo tse amanang le PRP.
Kaha batho ba bangata ba na le palo ea motheo ea platelet ea 200,000±75,000 ka μl, palo ea platelet ea PRP e limilione tse 1 ka μl e lekantsoeng ka li-aliquot tse tloaelehileng tsa 6-ml e fetohile letšoao la "phekolo ea PRP."Habohlokoa, liphuputso li bontšitse hore motsoako ona oa platelet o finyelloa ha maemo a phekolo a fihletsoe, kahoo a lokolla lintlha tsa kholo.
(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)
Nako ea poso: Sep-01-2022