Li-platelet (thrombocyte) ke likotoana tse nyane tsa cytoplasm tse lokollotsoeng ho cytoplasm ea Megakaryocyte e holileng mokong oa masapo.Le hoja Megakaryocyte e le palo e fokolang ea lisele tsa hematopoietic mokong oa masapo, e leng karolo ea 0.05% feela ea palo eohle ea lisele tsa 'mele oa masapo, liplatelete tseo li li hlahisang li bohlokoa haholo bakeng sa mosebetsi oa' mele oa hemostatic.Megakaryocyte ka 'ngoe e ka hlahisa liplatelete tse 200-700.
Palo ea liplatelete tsa motho e moholo ea tloaelehileng ke (150-350) × 109/L.Li-platelet li na le mosebetsi oa ho boloka botšepehi ba marako a methapo ea mali.Ha palo ea liplatelete e fokotseha ho 50 × Ha khatello ea mali e le ka tlase ho 109 / L, ts'oaetso e nyane kapa khatello e eketsehileng ea mali e ka baka matheba a stasis ea mali letlalong le submucosa, esita le purpura e kholo.Lebaka ke hore li-platelet li ka lula leboteng la vascular ka nako leha e le efe ho tlatsa likheo tse siiloeng ke lisele tsa endothelial cell detachment, 'me li ka kopanya lisele tsa vascular endothelial, tse ka' nang tsa phetha karolo ea bohlokoa ho boloka botšepehi ba lisele tsa endothelial kapa ho lokisa lisele tsa endothelial.Ha liplatelete li fokola haholo, ho thata ho phetha mesebetsi ena ’me ho na le tšekamelo ea ho tsoa mali.Li-platelet maling a potolohang hangata li maemong a "emeng".Empa ha methapo ea mali e senyehile, liplatelete li kenngoa ts'ebetsong ka ho kopana holimo le ketso ea lintlha tse itseng tsa coagulation.Li-platelet tse sebetsang li ka lokolla letoto la lintho tse hlokahalang bakeng sa ts'ebetso ea hemostatic le ho sebelisa mesebetsi ea 'mele e kang ho khomarela, ho kopanya, ho lokolla le ho bapatsa.
Platelet e hlahisang Megakaryocyte le eona e tsoa liseleng tsa stem tsa hematopoietic mokong oa masapo.Lisele tsa "hematopoietic stem" li qala ho arohana ka lisele tsa megakaryocyte progenitor, tse tsejoang hape e le colony forming unit megakaryocyte (CFU Meg).Li-chromosome tse khubung ea sethala sa lisele tsa progenitor hangata li na le 2-3 ploidy.Ha lisele tsa progenitor li le diploid kapa tetraploid, lisele li na le bokhoni ba ho ata, kahoo ena ke sethala ha mela ea Megakaryocyte e eketsa palo ea lisele.Ha lisele tsa progenitor tsa megakaryocyte li tsoela pele ho aroloa ho 8-32 ploidy Megakaryocyte, cytoplasm e ile ea qala ho khetholla 'me tsamaiso ea Endomembrane ea phethoa butle-butle.Qetellong, ntho ea lera e arola cytoplasm ea Megakaryocyte libakeng tse ngata tse nyenyane.Ha sele ka 'ngoe e arohane ka ho feletseng, e fetoha platelet.Ka bonngoe, li-platelet li theoha ho Megakaryocyte ka lekhalo le pakeng tsa lisele tsa endothelial tsa lerako la sinus la mothapo ebe li kena maling.
Ho ba le thepa e fapaneng ka ho felletseng ea immunological.TPO ke glycoprotein e hlahisoang haholo ke liphio, e nang le boima ba molek'hule bo ka bang 80000-90000.Ha liplatelete maling li fokotseha, khatello ea TPO maling ea eketseha.Mesebetsi ea ntlha ena ea taolo e kenyelletsa: ① ho matlafatsa motsoako oa DNA liseleng tsa pele le ho eketsa palo ea lisele tsa polyploid;② E susumetsa Megakaryocyte ho etsa protheine;③ Eketsa palo eohle ea Megakaryocyte, e leng se hlahisang tlhahiso e eketsehileng ea platelet.Hona joale, ho lumeloa hore ho ata le ho arohana ha Megakaryocyte ho laoloa haholo-holo ke lintlha tse peli tsa taolo ka mekhahlelo e 'meli ea phapang.Lilaoli tsena tse peli ke megakaryocyte Colony-stimulating factor (Meg CSF) le Thrombopoietin (TPO).Meg CSF ke ntho e laolang haholo-holo e sebetsang sethaleng sa lisele tsa progenitor, 'me karolo ea eona ke ho laola ho ata ha lisele tsa megakaryocyte progenitor.Ha palo eohle ea Megakaryocyte mokong oa masapo e fokotseha, tlhahiso ea ntlha ena ea taolo ea eketseha.
Ka mor'a hore liplatelete li kene maling, li na le mesebetsi ea 'mele feela matsatsing a mabeli a pele, empa bophelo ba bona bo tloaelehileng bo ka ba matsatsi a 7-14.Mesebetsing ea physiological hemostatic, liplatelete ka botsona li tla qhalana ebe li lokolla lintho tsohle tse sebetsang kamora ho kopana;E ka boela ea kenyelletsa liseleng tsa vascular endothelial.Ntle le botsofali le timetso, liplatelete le tsona li ka jeoa nakong ea ts'ebetso ea tsona ea 'mele.Liplatelete tse tsofetseng li koaheloa ke spleen, sebete le lisele tsa matšoafo.
1. Ultrastructure ea liplatelete
Tlas'a maemo a tloaelehileng, liplatelete li hlaha e le li-discs tsa convex hanyenyane mahlakoreng ka bobeli, ka bophara ba bophara ba 2-3 μ m.Ka karolelano molumo ke 8 μ M3.Liplatelete ke lisele tse nang le nucleated tse se nang sebopeho se khethehileng tlas'a microscope ea optical, empa ultrastructure e rarahaneng e ka bonoa tlas'a microscope ea elektronike.Hona joale, sebopeho sa li-platelet ka kakaretso se arotsoe ka libaka tse potolohileng, sebaka sa gel sol, sebaka sa Organelle le sebaka se khethehileng sa membrane system.
Sebaka se tloaelehileng sa platelet se boreleli, 'me ho na le likarolo tse nyenyane tsa concave tse bonahalang,' me ke tsamaiso e bulehileng ea canalicular (OCS).Sebaka se potolohileng sebaka sa platelet se entsoe ka likarolo tse tharo: lera le ka ntle, lesela la yuniti, le sebaka sa submembrane.Seaparo sena haholo-holo se entsoe ka li-glycoprotein tse sa tšoaneng (GP), tse kang GP Ia, GP Ib, GP IIa, GP IIb, GP IIIa, GP IV, GP V, GP IX, joalo-joalo E etsa mefuta e sa tšoaneng ea li-receptor tse khomarelang 'me e ka kopanya. ho TSP, thrombin, collagen, fibrinogen, joalo-joalo. Ho bohlokoa hore liplatelete li kenye letsoho ho coagulation le taolo ea 'mele ea ho itšireletsa mafung.Lera la yuniti, le tsejoang hape e le lera la plasma, le na le likaroloana tsa protheine tse kentsoeng ka har'a lipid bilayer.Palo le kabo ea likaroloana tsena li amana le ho khomarela platelet le mosebetsi oa ho kopanya.Lera le na le Na + - K + - ATPase, e bolokang phapang ea mahloriso ea ion ka hare le ka ntle ho lera.Sebaka sa submembrane se pakeng tsa karolo e ka tlaase ea lera la yuniti le lehlakoreng le ka ntle la microtubule.Sebaka sa Submembrane se na le likhoele tsa submembrane le Actin, tse amanang le ho khomarela le ho kopanya liplatelete.
Li-microtubules, microfilaments le submembrane filaments le tsona li teng sebakeng sa sol gel ea liplatelete.Lintho tsena li etsa skeleton le contraction system ea liplatelete, tse bapalang karolo ea bohlokoa ho holofatseng ha liplatelete, ho lokolloa ha likaroloana, ho otlolla le ho honyela ha lehlo.Li-microtubules li entsoe ka Tubulin, e etsang karolo ea 3 lekholong ea protheine ea platelet.Mosebetsi oa bona o ka sehloohong ke ho boloka sebopeho sa liplatelete.Li-microfilaments li na le Actin, e leng protheine e ngata ka ho fetisisa liplateleteng 'me e nka 15% ~ 20% ea kakaretso ea protheine ea platelet.Li-submembrane filaments haholo-holo ke likaroloana tsa fiber, tse ka thusang Actin-tlamang protheine le Actin crosslink ho etsa dingata hammoho.Ka lebaka la boteng ba Ca2 +, actin e sebelisana le prothrombin, contractin, protheine e tlamang, co actin, myosin, joalo-joalo ho phethahatsa phetoho ea sebopeho sa platelet, sebopeho sa pseudopodium, contraction ea sele le liketso tse ling.
Letlapa la 1 Letlapa le ka Sehloohong la Membrane Glycoproteins
Sebaka sa Organelle ke sebaka seo ho sona ho nang le mefuta e mengata ea Organelle ka har'a li-platelet, tse nang le tšusumetso ea bohlokoa mosebetsing oa li-platelet.Hape ke sebaka sa lipatlisiso tsa bongaka ba sejoale-joale.Likarolo tsa bohlokoa ka ho fetisisa sebakeng sa Organelle ke likaroloana tse fapaneng, tse kang α Particles, particles tse teteaneng (δ Particles) le Lysosome ( λ Particles, joalo-joalo, bona Lethathamo la 1 bakeng sa lintlha tse ling.α Granules ke libaka tsa polokelo ea liplatelete tse ka hlahisang liprotheine.Ho na le tse fetang leshome platelet ka 'ngoe α Particles.Lethathamo la 1 le thathamisa feela likarolo tse batlang li le kholo, 'me ho latela lipatlisiso tsa mongoli, ho fumanoe hore α Ho na le maemo a fetang 230 a lintlha tse tsoang ho platelet (PDF) tse teng ka har'a granules.Tekanyo e teteaneng ea likaroloana α Likaroloana li nyane hanyane, ka bophara ba 250-300nm, 'me ho na le likaroloana tse teteaneng tse 4-8 ho platelet ka' ngoe.Hona joale, ho fumanoe hore 65% ea ADP le ATP li bolokiloe ka likaroloana tse teteaneng ka har'a li-platelet, 'me 90% ea 5-HT maling e boetse e bolokiloe ka likaroloana tse teteaneng.Ka hona, likaroloana tse teteaneng li bohlokoa bakeng sa ho bokellana ha platelet.Bokhoni ba ho lokolla ADP le 5-HT bo ntse bo sebelisoa ka bongaka ho lekola tšebetso ea secretion ea platelet.Ntle le moo, sebaka sena se boetse se na le mitochondria le Lysosome, eo hape e leng sebaka sa lipatlisiso lapeng le kantle ho naha selemong sena.2013 Nobel Prize in Physiology and Medicine e ile ea fuoa bo-rasaense ba bararo, James E. Rothman, Randy W. Schekman, le Thomas C. S ü dhof, bakeng sa ho sibolla liphiri tsa mekhoa ea lipalangoang tsa intracellular.Ho boetse ho na le masimo a mangata a sa tsejoeng ho metabolism ea lintho le matla liplatelete ka 'mele oa intracellular le Lysosome.
Sebaka se ikhethileng sa membrane se kenyelletsa OCS le dense tubular system (DTS).OCS ke tsamaiso e thata ea liphaephe tse entsoeng ke bokaholimo ba li-platelet tse theohelang ka hare ho li-platelet, tse eketsang haholo sebaka sa li-platelet tse amanang le plasma.Ka nako e ts'oanang, ke kanale ea kantle ho sele ea hore lintho tse fapaneng li kene liplatelete ebe li lokolla likarolo tse fapaneng tsa liplatelete.Pipe ea DTS ha e kopane le lefats'e le ka ntle 'me ke sebaka sa motsoako oa lintho tse ka har'a lisele tsa mali.
2. Mosebetsi oa Physiological oa Platelet
Mosebetsi o ka sehloohong oa 'mele oa liplatelete ke ho kenya letsoho ho hemostasis le thrombosis.Ts'ebetso ea liplatelete nakong ea hemostasis ea fisioloji e ka aroloa ka mekhahlelo e 'meli: hemostasis ea pele le hemostasis ea bobeli.Li-platelet li phetha karolo ea bohlokoa mekhahlelong e 'meli ea hemostasis, empa mekhoa e tobileng eo li sebetsang ka eona e ntse e fapana.
1) Ts'ebetso ea pele ea hemostatic ea liplatelete
The thrombus e entsoeng nakong ea pele ea hemostasis ke haholo-holo thrombus e tšoeu, 'me liketso tsa ts'ebetso tse kang platelet adhesion, deformation, tokollo, le aggregation ke mekhoa ea bohlokoa ts'ebetsong ea mantlha ea hemostasis.
I. Platelet adhesion reaction
Ho khomarela pakeng tsa liplatelete le libaka tse seng tsa platelet ho bitsoa platelet adhesion, e leng mohato oa pele oa ho kenya letsoho liketsong tse tloaelehileng tsa hemostatic ka mor'a ho senyeha ha methapo le mohato oa bohlokoa oa pathological thrombosis.Ka mor'a kotsi ea methapo ea mali, liplatelete tse phallang ka sekepeng sena li sebelisoa ke bokaholimo ba lisele tse tlas'a vascular endothelium 'me hang-hang li khomarela likhoele tsa collagen tse pepenene sebakeng sa kotsi.Ka metsotso e 10, liplatelete tse kentsoeng sebakeng sa heno li ile tsa fihla boleng ba tsona bo phahameng, tsa etsa maqeba a masoeu a mali.
Lintlha tse ka sehloohong tse amehang ts'ebetsong ea ho khomarela liplatelete li kenyelletsa platelet membrane glycoprotein Ⅰ (GP Ⅰ), von Willebrand factor (vW factor) le collagen ka lisele tsa subendothelial.Mefuta e ka sehloohong ea collagen e teng leboteng la methapo ke mefuta ea I, III, IV, V, VI, le VII, eo har'a mefuta ea I, III, le IV ea collagen e leng ea bohlokoa ka ho fetisisa bakeng sa ts'ebetso ea ho khomarela platelet tlas'a maemo a phallang.Ntho ea vW ke borokho bo kopanyang ho khomarela liplatelete ho mofuta oa I, III, le IV collagen, 'me glycoprotein e khethehileng ea receptor GP Ib holim'a lera la platelet ke sebaka se ka sehloohong sa platelet collagen tlamang.Ho phaella moo, glycoproteins GP IIb / IIIa, GP Ia / IIa, GP IV, CD36, le CD31 ka lera la platelet le tsona li kenya letsoho ho khomarela collagen.
II.Boitšoaro ba platelet aggregation
Ketsahalo ea hore liplatelete li khomarelane li bitsoa aggregation.Boitšoaro ba ho kopanya bo etsahala ka karabelo ea ho khomarela.Ka pel'a Ca2+, platelet membrane glycoprotein GPIIb/IIIa le fibrinogen aggregate e qhalakantsoeng liplatelete hammoho.Platelet aggregation e ka susumetsoa ke mekhoa e 'meli e fapaneng, e' ngoe ke li-inducers tsa lik'hemik'hale tse fapaneng, 'me e' ngoe e bakoa ke khatello ea ho kuta tlas'a maemo a phallang.Qalong ea ho bokellana, liplatelete li fetoha ho tloha sebōpehong sa diski ho ea ho sebopeho se chitja 'me li hlahella ka maoto a mang a maiketsetso a kang meutloa e menyenyane;Ka nako e ts'oanang, degranulation ea platelet e bolela ho lokolloa ha lintho tse sebetsang tse kang ADP le 5-HT tseo qalong li neng li bolokiloe ka likaroloana tse teteaneng.Ho lokolloa ha ADP, 5-HT le tlhahiso ea Prostaglandin e 'ngoe ke tsa bohlokoa haholo bakeng sa ho kopanya.
ADP ke ntho ea bohlokoa ka ho fetisisa bakeng sa ho kopanya liplatelete, haholo-holo ADP ea tlhaho e tsoang liplatelete.Eketsa palo e nyenyane ea ADP (ho tsepamisa mohopolo ho 0.9) ho emisoa ha platelet μ Ka tlaase ho mol / L), e ka baka kapele ho bokellana ha platelet, empa ka potlako ho senya;Haeba litekanyetso tse itekanetseng tsa ADP (1.0) li eketsoa μ Hoo e ka bang mol / L, mohato oa bobeli oa ho bokellana o ke keng oa fetoloa o etsahala nakoana ka mor'a ho fela ha karolo ea pele ea ho kopanya le karolo ea depolymerization, e bakoang ke ADP ea endogenous e lokolloa ke liplatelete;Haeba palo e kholo ea ADP e eketsoa, ka potlako e baka kopano e ke keng ea fetoloa, e kenang ka ho toba karolong ea bobeli ea ho kopanya.Ho eketsa litekanyetso tse fapaneng tsa thrombin ho emisoa ha platelet le hona ho ka baka ho kopana ha platelet;'Me e ts'oanang le ADP, ha litekanyetso li ntse li eketseha butle-butle, ho bokellana ka mokhoa o tsosolositsoeng ho ka bonoa ho tloha karolong ea pele feela ho ea ho ponahalo ea mekhahlelo e' meli ea ho kopanya, ebe e kena ka ho toba karolong ea bobeli ea ho kopanya.Hobane ho thibela ho lokolloa ha ADP ea tlhaho ka adenosine ho ka thibela ho kopana ha platelet ho bakoang ke thrombin, ho fana ka maikutlo a hore phello ea thrombin e ka bakoa ke ho tlama ha thrombin ho li-receptor tsa thrombin holim'a lera la platelet cell, e leng se lebisang ho lokolloeng ha ADP ea endogenous.Ho eketsoa ha collagen ho ka boela ha etsa hore platelet aggregation e emisoe, empa ho kopanngoa feela ho ke keng ha fetoloa karolong ea bobeli ho lumeloa hore hangata ho bakoa ke ho lokolloa ha ADP ho bakoang ke collagen.Lintho tseo ka kakaretso li ka bakang ho kopana ha liplatelete li ka fokotsa cAMP ka har'a liplatelete, ha tse thibelang ho kopana ha platelet li eketsa cAMP.Ka hona, ha joale ho lumeloa hore ho fokotseha ha cAMP ho ka baka keketseho ea Ca2+ li-platelet, ho khothalletsa ho lokolloa ha ADP ea endogenous.ADP e baka pokello ea liplatelete, e hlokang boteng ba Ca2+ le fibrinogen, hammoho le tšebeliso ea matla.
Karolo ea platelet Prostaglandin Phospholipid ea platelet plasma membrane e na le Arachidonic acid, 'me sele ea platelet e na le Phosphatidic acid A2.Ha liplatelete li sebetsa ka holim'a metsi, Phospholipase A2 le eona e ea sebetsa.Tlas'a catalysis ea Phospholipase A2, Arachidonic acid e arotsoe ho phospholipids ka lera la plasma.Arachidonic acid e ka etsa palo e kholo ea TXA2 tlas'a catalysis ea platelet cyclooxygenase le Thromboxane synthase.TXA2 e fokotsa cAMP ka har'a li-platelet, e bakang ho kopana ho matla ha platelet le phello ea vasoconstriction.TXA2 le eona ha e tsitsa, kahoo e fetoha TXB2 e sa sebetseng kapele.Ho phaella moo, lisele tse tloaelehileng tsa vascular endothelial li na le prostacyclin synthase, e ka etsang hore ho be le tlhahiso ea prostacyclin (PGI2) ho tloha liplatelete.PGI2 e ka eketsa cAMP ho li-platelet, kahoo e na le phello e matla ea ho thibela platelet aggregation le Vasoconstriction.
Adrenaline e ka fetisoa ka α 2. Phatlalatso ea Adrenergic receptor e ka baka biphasic platelet aggregation, e nang le mahloriso a (0.1 ~ 10) μ Mol / L.Thrombin maemong a tlase (<0.1 μ At mol / L, karolo ea pele ea ho kopanya liplatelete e bakoa haholo-holo ke PAR1; Libakeng tse phahameng (0.1-0.3) μ Ka mol / L, karolo ea bobeli ea ho kopanya e ka hlahisoa ke PAR1 le PAR4 . Li-inducers tse matla tsa platelet aggregation li boetse li kenyelletsa platelet activating factor (PAF), collagen, vW factor, 5-HT, joalo-joalo. Platelet aggregation e ka boela ea susumetsoa ka ho toba ke tšebetso ea mochine ntle le inducer. lefu la atherosclerosis.
III.Karabelo ea ho lokolloa ha platelet
Ha liplatelete li le tlas'a ts'usumetso ea 'mele, li bolokiloe ka likaroloana tse teteaneng α Ketsahalo ea lintho tse ngata ka likaroloana le li-lysosomes tse ntšoang liseleng li bitsoa karabelo ea tokollo.Mosebetsi oa liplatelete tse ngata o finyelloa ka liphello tsa likokoana-hloko tsa lintho tse entsoeng kapa tse lokolloa nakong ea karabelo ea tokollo.Hoo e ka bang li-inducers tsohle tse bakang platelet aggregation li ka baka karabelo ea tokollo.Karabelo ea tokollo hangata e etsahala kamora ho kopanngoa ha liplatelete tsa mohato oa pele, 'me ntho e hlahisoang ke karabelo ea tokollo e susumetsa karolo ea bobeli.Li-inducers tse bakang karabelo ea tokollo li ka aroloa ka likarolo tse latelang:
ke.Inducer e fokolang: ADP, adrenaline, Norepinephrine, vasopressin, 5-HT.
ii.Li-inducers tse mahareng: TXA2, PAF.
iii.Li-inducers tse matla: thrombin, enzyme ea pancreatic, collagen.
2) Karolo ea liplatelete ho coagulation ea mali
Liplatelete li nka karolo haholo liketsong tse fapaneng tsa coagulation ka phospholipids le membrane glycoprotein, ho kenyeletsoa adsorption le activation of coagulation factor (lintlha IX, XI, le XII), ho theha coagulation e khothalletsang likhoele holim'a phospholipid membranes, le nts'etsopele ea sebopeho sa prothrombin.
Lera la plasma holim'a li-platelet le tlama ho mabaka a sa tšoaneng a coagulation, a kang fibrinogen, factor V, factor XI, factor XIII, joalo-joalo. 'me PF3 ka bobeli li khothalletsa ho kopana ha mali.PF4 e ka fokotsa heparin, ha PF6 e thibela fibrinolysis.Ha liplatelete li kentsoe holim'a metsi, li ka potlakisa ts'ebetso ea ts'ebetso ea holim'a coagulation factor XII le XI.Sebaka sa phospholipid (PF3) se fanoeng ke liplatelete ho hakanngoa hore se potlakisa ts'ebetso ea prothrombin ka makhetlo a 20000.Ka mor'a ho kopanya lintlha tsa Xa le V holim'a phospholipid ena, li ka boela tsa sireletsoa liphellong tsa inhibitory tsa antithrombin III le heparin.
Ha liplatelete li kopana ho theha hemostatic thrombus, ts'ebetso ea ho kopanya e se e etsahetse sebakeng sa heno, 'me liplatelete li pepesitse bokaholimo ba phospholipid, ho fana ka maemo a matle haholo bakeng sa ts'ebetso ea factor X le prothrombin.Ha liplatelete li hlohlelletsoa ke collagen, thrombin kapa kaolin, Sphingomyelin le Phosphatidylcholine tse ka ntle ho lera la platelet li fetoha le phosphatidyl Ethanolamine le phosphatidylserine ka hare, e leng se hlahisang keketseho ea phosphatidyl Ethanolamine le lera la phosphatidyl holim'a bokaholimo.Lihlopha tse kaholimo tsa phosphatidyl li ile tsa phethola holim'a liplatelete li nka karolo ho thehoeng ha li-vesicles holim'a membrane nakong ea ts'ebetso ea platelet.Li-vesicles lia arohana ebe li kena maling ho etsa li-microcapsules.Li-vesicles le li-microcapsules li na le phosphatidylserine e ngata, e thusang ho kopanya le ho kenya ts'ebetsong ea prothrombin le ho kenya letsoho ts'ebetsong ea ho khothalletsa ho kopana ha mali.
Ka mor'a hore platelet aggregation, eona α Ho lokolloa ha likarolo tse sa tšoaneng tsa platelet ka likaroloana ho khothalletsa ho thehoa le ho eketseha ha likhoele tsa mali, 'me ho tšoasa lisele tse ling tsa mali ho etsa maqeba.Ka hona, le hoja liplatelete li senyeha butle-butle, emboli ea hemostatic e ntse e ka eketseha.Li-platelet tse setseng leqebeng la mali li na le pseudopodia e fetelang marangrang a fiber ea mali.Liprotheine tsa contractile li-platelet tsena lia honyela, li etsa hore leqeba la mali le hohele, le ntše serum ebe le fetoha polaka e tiileng ea hemostatic, e koalang lekhalo la methapo ka tieo.
Ha o kenya li-platelet le tsamaiso ea coagulation holim'a metsi, e boetse e kenya tšebetsong tsamaiso ea fibrinolytic.Plasmin le activator ea eona e ka har'a liplatelete li tla lokolloa.Ho lokolloa ha serotonin ho tsoa ho likhoele tsa mali le liplatelete ho ka boela ha etsa hore lisele tsa endothelial li lokolle li-activator.Leha ho le joalo, ka lebaka la ho arohana ha liplatelete le ho lokolloa ha PF6 le lintho tse ling tse thibelang li-protease, ha li amehe ke mosebetsi oa fibrinolytic nakong ea ho thehoa ha mali.
(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)
Nako ea poso: Jun-13-2023