Androgenic alopecia (AGA), mofuta o tloaelehileng oa ho lahleheloa ke moriri, ke lefu le tsoelang pele la ho lahleheloa ke moriri le qalang lilemong tsa bocha kapa lilemong tsa bocha.Ho ata ha banna naheng ea heso ho ka ba 21.3%, 'me ho ata ha basali ke hoo e ka bang 6.0%.Leha litsebi tse ling li hlahisitse litataiso bakeng sa tlhahlobo le kalafo ea alopecia ea androgenetic naheng ea China nakong e fetileng, li shebane haholo le tlhahlobo le kalafo ea kalafo ea AGA, 'me likhetho tse ling tsa kalafo li batla li haella.Lilemong tsa morao tjena, ka ho hatisoa kalafo ea AGA, mekhoa e meng e mecha ea phekolo e hlahile.
Etiology le Pathogenesis
AGA ke lefutso la lefutso la polygenic recessive disorder.Liphuputso tsa malapa a lefu la seoa li bontša hore 53.3% -63.9% ea bakuli ba AGA ba na le histori ea malapa, 'me moloko oa ntate o phahame haholo ho feta oa bakhachane.Lithuto tsa morao-rao tsa tatellano ea liphatsa tsa lefutso le limmapa li bonts'itse mefuta e mengata ea ts'oaetso, empa liphatsa tsa bona tsa pathogenic ha li so tsejoe.Lipatlisiso tsa morao-rao li bontša hore li-androgens li phetha karolo ea bohlokoa ho pathogenesis ea AGA;lintlha tse ling tse kenyeletsang ho ruruha ho pota-potileng moriri oa moriri, khatello e eketsehileng ea bophelo, tsitsipano le matšoenyeho, le mekhoa e fokolang ea ho phela le ho ja li ka mpefatsa matšoao a AGA.Li-Androgens ho banna haholo-holo li tsoa ho testosterone e hlahisoang ke li-testes;androgens ho basali haholo-holo li tsoa ho motsoako oa adrenal cortex le tekanyo e nyenyane ea secretion ho tloha mae a bomme, androgen ke haholo-holo androstenediol, e ka fetoloang ho testosterone le dihydrotestosterone.Le hoja li-androgens e le ntlha ea bohlokoa ho pathogenesis ea AGA, litekanyetso tsa androgen tse potolohang hoo e batlang e le bakuli bohle ba AGA li bolokiloe maemong a tloaelehileng.Liphuputso li bontšitse hore phello ea li-androgens ho li-follicle tsa moriri tse nang le ts'oaetso e eketseha ka lebaka la ho eketseha ha liphatsa tsa lefutso tsa androgen receptor le / kapa ho eketseha ha polelo ea mofuta oa II 5α reductase liphatsa tsa moriri sebakeng sa alopecia.Bakeng sa AGA, dermal component cell of susceptible hair follicles e na le mofuta o itseng oa II 5α reductase, o ka fetolang testosterone ea androgen e potolohang sebakeng sa mali ho dihydrotestosterone ka ho tlama ho intracellular androgen receptor.Ho qala letoto la liketso tse lebisang ho ho fokotseha ho hoholo ha li-follicles tsa moriri le ho lahleheloa ke moriri ho lefatla.
Litlhahiso tsa Tleliniki le Litlhahiso tsa Kalafo
AGA ke mofuta oa alopecia e sa hlabang eo hangata e qalang nakong ea bocha 'me e khetholloa ka ho fokotseha ho tsoelang pele ha bophara ba moriri, ho lahleheloa ke moriri o teteaneng, le alopecia ho fihlela litekanyo tse sa tšoaneng tsa lefatla, hangata li tsamaea le matšoao a ho eketseha ha oli ea letlalo la hlooho.
Kopo ea PRP
Khatello ea liplatelete e lekana le concentrate ea makhetlo a 4-6 a platelet maling kaofela.Hang ha PRP e sebelisoa, li-granules tsa α li-platelet li tla lokolla palo e kholo ea lintlha tsa khōlo, ho akarelletsa le platelet-derived growth factor, ho fetola sekhahla sa kholo-β, insulin-like growth factor, epidermal growth factor le vascular endothelial growth factor, joalo-joalo. ea ho khothalletsa ho hōla ha follicle ea moriri, empa mokhoa o khethehileng oa ts'ebetso ha o hlake ka ho feletseng.Tšebeliso ke ho kenya PRP sebakeng sa heno ho dermis lera ea letlalo sebakeng sa alopecia, hang ka khoeli, 'me liente tse tsoelang pele 3 ho linako tse 6 li ka bona phello e itseng.Le hoja lithuto tse fapa-fapaneng tsa kliniki lapeng le linaheng tse ling li tiisitse esale pele hore PRP e na le phello e itseng ho AGA, ha ho na mokhoa o ts'oanang oa ho lokisoa ha PRP, kahoo tekanyo e sebetsang ea phekolo ea PRP ha e tšoane, 'me e ka sebelisoa e le thuso. mokhoa oa ho phekola AGA mothating ona.
(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)
Nako ea poso: Aug-02-2022