Histori ea Platelet Rich Plasma (PRP)

Mabapi le Platelet Rich Plasma (PRP)

Platelet-rich plasma (PRP) e na le boleng ba phekolo bo bapisoang le lisele tsa stem 'me hona joale ke e' ngoe ea mekhoa ea phekolo e tšepisang ka ho fetisisa meriana ea ho tsosolosa.E sebelisoa haholo mafapheng a fapaneng a bongaka, ho kenyelletsa le cosmetic dermatology, orthopedics, meriana ea lipapali le opereishene.

Ka 1842, ho ile ha sibolloa lintho tse ling ntle le lisele tse khubelu le tse tšoeu tsa mali maling, e leng se ileng sa makatsa batho ba mehleng ea hae.Julius Bizozero e bile oa pele oa ho reha sebopeho se secha sa platelet "le piastrine del sangue" - liplatelete.Ka 1882, o ile a hlalosa karolo ea liplatelete ho coagulation in vitro le ho kenya letsoho ha bona ho etiology ea thrombosis ka vivo.O ile a boela a fumana hore marako a methapo ea mali a thibela ho khomarela platelet.Wright o ile a tsoela pele ho ntlafatsa mekhoa ea phekolo e nchafatsang ka ho sibolla ha hae li-macrokaryocyte, tseo e leng tsona tse tlang pele ho liplatelete.Mathoasong a lilemo tsa bo-1940, lingaka li ne li sebelisa "li-extracts" tsa embryonic tse entsoeng ka lintlha tsa kholo le li-cytokine ho khothalletsa pholiso ea maqeba.Pholiso e potlakileng le e sebetsang ea maqeba ke ea bohlokoa bakeng sa katleho ea mekhoa ea ho buoa.Ka hona, Eugen Cronkite et al.e ile ea hlahisa motsoako oa thrombin le fibrin ka li-grafts tsa letlalo.Ka ho sebelisa likarolo tse ka holimo, ho tiisetsoa ho khomarela ho tiileng le ho tsitsitseng ha flap, e leng se phethang karolo ea bohlokoa mofuteng ona oa ho buuoa.

Mathoasong a lekholo la bo20 la lilemo, lingaka li ile tsa hlokomela tlhokahalo e potlakileng ea ho tšela li- platelet ho phekola thrombocytopenia.Sena se lebisitse ho ntlafatso ea mekhoa ea ho lokisa concentrate ea platelet.Ho tlatselletsa ka metsoako ea platelet ho ka thibela ho tsoa mali ho bakuli.Ka nako eo, lingaka le litsebi tsa mali tsa laboratori li ile tsa leka ho lokisa li- platelet concentrate bakeng sa tšelo ea mali.Mekhoa ea ho fumana li-concentrates e tsoetse pele ka potlako mme e ntlafetse haholo, kaha lipoleiti tse arohaneng li lahleheloa ke matla a tsona ka potlako 'me kahoo li tlameha ho bolokoa ho 4 °C le ho sebelisoa nakong ea lihora tse 24.

Lisebelisoa le mekhoa

Lilemong tsa bo-1920, citrate e ne e sebelisoa e le anticoagulant ho fumana metsoako ea platelet.Khatelo-pele ea ho lokisa li- platelet concentrate e ile ea potlakisa lilemong tsa bo-1950 le bo-1960 ha ho ne ho etsoa litšelo tsa mali tsa polasetiki tse tenyetsehang.Poleloana "plasma e ruileng ea platelet" e qalile ho sebelisoa ke Kingsley et al.ka 1954 ho bua ka li- platelet concentrates tse tloaelehileng tse sebelisetsoang tšelo ea mali.Lisebelisoa tsa pele tsa PRP tsa banka ea mali li ile tsa hlaha lilemong tsa bo-1960 'me tsa tsebahala lilemong tsa bo-1970.Ho elella bofelong ba lilemo tsa bo-1950 le bo-1960, ho ile ha sebelisoa "EDTA platelet packs".Setha sena se na le mokotla oa polasetiki o nang le mali a EDTA a lumellang hore liplatelete li kenngoe ke centrifugation, tse lulang li emisitsoe ka tekanyo e nyenyane ea plasma ka mor'a ho buuoa.

Sephetho

Ho nahanoa hore lintlha tsa kholo (GFs) ke metsoako e meng ea PRP e patoang ho tloha liplatelete 'me e ameha ketsong ea eona.Khopolo-taba ena e tiisitsoe ka bo-1980.Hoa fumaneha hore liplatelete li lokolla limolek'hule tsa bioactive (GFs) ho lokisa lisele tse senyehileng, joalo ka liso tsa letlalo.Ho fihlela joale, ho entsoe lithuto tse 'maloa tse hlahlobang taba ena.E 'ngoe ea lithuto tse ithutoang haholo lefapheng lena ke motsoako oa PRP le hyaluronic acid.Epidermal growth factor (EGF) e ile ea fumanoa ke Cohen ho 1962. Li-GF tse latelang e ne e le platelet-derived growth factor (PDGF) ka 1974 le vascular endothelial growth factor (VEGF) ho 1989.

Ka kakaretso, tsoelo-pele litabeng tsa bongaka le eona e lebisitse tsoelopeleng e potlakileng ea tšebeliso ea liplatelete.Ka 1972, Matras o ile a sebelisa liplatelete ka lekhetlo la pele e le sekontiri ho theha mali a homeostasis nakong ea opereishene.Ho feta moo, ka 1975, Oon le Hobbs e bile bo-ramahlale ba pele ba ho sebelisa PRP kalafong e nchafatsang.Ka 1987, Ferrari et al o ile a qala ho sebelisa plasma e nang le liplatelete tse ngata e le mohloli o ikemetseng oa tšelo ea mali ho opereishene ea pelo, ka hona a fokotsa tahlehelo ea mali e sa sebetseng, mathata a mali a phallo ea mali, le tšebeliso e latelang ea lihlahisoa tsa mali.

Ka 1986, Knighton et al.e bile bo-ramahlale ba pele ba ho hlalosa protocol ea ntlafatso ea liplatelete mme ba e reha lebitso la autologous platelet-derived ulcer factor (PDWHF).Ho tloha ha ho thehoa protocol, mokhoa ona o 'nile oa sebelisoa haholo meriana ea botle.PRP e 'nile ea sebelisoa meriana e tsosolosang ho tloha bofelong ba lilemo tsa bo-1980.

Ntle le ho buuoa ka kakaretso le opereishene ea pelo, opereishene ea maxillofacial e ne e le sebaka se seng moo PRP e ileng ea tsebahala mathoasong a lilemo tsa bo-1990.PRP e ne e sebelisetsoa ho ntlafatsa tlamahano ea graft ho tsosolosoa ha mandibular.PRP e boetse e qalile ho kenngoa ts'ebetsong ea meno 'me e' nile ea sebelisoa ho tloha bofelong ba 1990 ho ntlafatsa tlamahano ea ho kenngoa ha meno le ho khothalletsa ho tsosolosoa ha masapo.Ho phaella moo, sekhomaretsi sa fibrin e ne e le ntho e tsebahalang haholo e amanang le eona e neng e hlahisoa ka nako eo.Tšebeliso ea PRP ho ngaka ea meno e ile ea ntlafatsoa ka ho eketsehileng ka ho qaptjoa ha platelet-rich fibrin (PRF), concentrate ea platelet e sa hlokeng ho eketsoa ha li-anticoagulants, ka Choukroun.

PRF e ile ea tsebahala haholo mathoasong a lilemo tsa bo-2000, ka palo e ntseng e eketseha ea lits'ebetso tsa meno, ho kenyelletsa le ho nchafatsoa ha lisele tsa hyperplastic gingival le bofokoli ba periodontal, ho koaloa ha leqeba la palatal, kalafo ea ho putlama ha gingival, le matsoho a ho ntšoa.

Buisanang

Anitua ho 1999 o hlalositse tšebeliso ea PRP ho khothalletsa ho tsosolosoa ha masapo nakong ea phapanyetsano ea plasma.Ka mor'a ho bona liphello tse molemo tsa phekolo, bo-rasaense ba ile ba batlisisa ketsahalo ena ho ea pele.Lipampiri tsa hae tse latelang li ile tsa tlaleha liphello tsa mali ana lisong tse sa foleng tsa letlalo, ho kenngoa ha meno, pholiso ea mesifa le likotsi tsa lipapali tsa masapo.Lithethefatsi tse 'maloa tse kenyang PRP, tse kang calcium chloride le bovine thrombin, li' nile tsa sebelisoa ho tloha ka 2000.

Ka lebaka la thepa ea eona e babatsehang, PRP e sebelisoa ho orthopaedics.Liphello tsa thuto ea pele e tebileng ea liphello tsa ho hōla ha lisele tsa tendon tsa motho li ile tsa hatisoa ka 2005. Phekolo ea PRP e sebelisoa hona joale ho phekola maloetse a fokolang le ho khothalletsa pholiso ea li-tendon, ligaments, mesifa le lefufuru.Lipatlisiso li fana ka maikutlo a hore ho tsebahala ho tsoelang pele ha mokhoa ona ho lingaka tsa masapo ho ka boela ha amana le tšebeliso ea khafetsa ea PRP ke linaleli tsa lipapali.Ka 2009, thuto ea liphoofolo ea liteko e ile ea hatisoa e tiisang khopolo ea hore PRP e tsepamisa maikutlo ho ntlafatsa pholiso ea mesifa ea mesifa.Mokhoa o ka sehloohong oa ts'ebetso ea PRP letlalong hona joale ke taba ea lipatlisiso tse matla tsa saense.

PRP e sebelisitsoe ka katleho ho cosmetic dermatology ho tloha 2010 kapa pejana.Ka mor'a ho kenya PRP, letlalo le shebahala le le monyenyane 'me hydration, ho feto-fetoha ha maemo le mmala li ntlafatsoa haholo.PRP e boetse e sebelisoa ho ntlafatsa kholo ea moriri.Ho na le mefuta e 'meli ea PRP e sebelisoang hona joale bakeng sa phekolo ea ho hōla ha moriri - plasma e sa sebetseng ea platelet-rich (A-PRP) le plasma e sebetsang e nang le platelet e ngata (AA-PRP).Leha ho le joalo, Balichaba et al.e bontšitse hore palo ea moriri le palo ea moriri e ka ntlafatsoa ka ho enta A-PRP.Ho feta moo, ho 'nile ha pakoa hore ho sebelisa phekolo ea PRP pele ho ho fetisoa ha moriri ho ka ntlafatsa kholo ea moriri le ho teteana ha moriri.Ho phaella moo, ka 2009, liphuputso li bontšitse hore tšebeliso ea motsoako oa PRP le mafura a ka ntlafatsa ho amoheloa ha mafura le ho phela, e leng se ka ntlafatsang liphello tsa opereishene ea polasetiki.

Liphuputso tsa morao-rao tse tsoang ho Cosmetic Dermatology li bontša hore motsoako oa PRP le CO2 laser therapy e ka fokotsa maqeba a makhopho haholo.Ka mokhoa o ts'oanang, PRP le microneedling li ile tsa fella ka li-bundle tse hlophisitsoeng tsa collagen letlalong ho feta PRP feela.Histori ea PRP ha e khutšoanyane, 'me liphuputso tse amanang le karolo ena ea mali li bohlokoa.Lingaka le bo-rasaense ba ntse ba batla mekhoa e mecha ea phekolo.E le mokhoa, PRP e sebelisoa likarolong tse ngata tsa bongaka, ho akarelletsa le mafu a basali, urology, le ophthalmology.

Nalane ea PRP ke bonyane lilemo tse 70.Ka hona, mokhoa ona o thehiloe hantle 'me o ka sebelisoa haholo meriana.

(Likahare tsa sengoloa sena li hatisitsoe hape, 'me ha re fane ka tiisetso efe kapa efe e hlakileng kapa e boletsoeng bakeng sa ho nepahala, ho ts'epahala kapa botlalo ba litaba tse teng sengolong sena,' me ha re ikarabelle bakeng sa maikutlo a sengoloa sena, ka kopo utloisisa.)